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KMID : 1033920120080010015
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Journal of The Korean Academy of Geriatric Denstry
2012 Volume.8 No. 1 p.15 ~ p.19
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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) in old patients
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Kwon Tae-Geon
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Abstract
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Recent increase in old patients with bisphosphonate (BP) use greately influence the incidence ratio of Bisphosphonaterelated Osteonecrosis of the jaws (BRONJ). In Korea, life expectancy in female patient is gradually increasing and risk of postmanauposal osteoporosis is now one of the major nation-wide health problem. Because the Bisphosphonate is potent and efficient drug for osteoporosis, malignant bone tumor and metastatic bone disease, it is needed to prescribe this medicine for many patients even though we know the potential risk of jaw necrosis in long term coverage of the medicine. Various researches had proposed that the BRONJ is related with over-supression of osteoclastic activity and resultant problem in bone turnover. Other factors such as anti-angiogenesis, uncoupling of osteoblast-osteoclast equilibrium and jaw-specific microenvironment was suggested conttributing factors. Because the drug effect last longer than any other medicine, comphrehensive understanding of pathophysiology of the BRONJ is needed. Further clinical and basic research should be continued.
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KEYWORD
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Bisphosphonate, Jaw, Necrosis
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